Technetium-99m chelates as tumor visualizing agents
نویسندگان
چکیده
منابع مشابه
Synthesis and biological evaluation of technetium-99m-labeled deoxyglucose derivatives as imaging agents for tumor.
Three deoxyglucose (DG) derivatives, S-DG, MAG(3)-DG and MAMA-BA-DG, were synthesized and labeled successfully with high labeling yields and high radio-chemical purities. Biodistribution in tumor-bearing mice demonstrated that these three new (99m)Tc-deoxyglucose derivatives showed accumulation in tumor and high tumor-to-muscle ratios. Among them, the (99m)Tc-MAG(3)-DG showed the best character...
متن کاملtechnetium-99m subtraction scanning
Solitary parathyroid adenomas were correctly located before surgery in 20 out of 21 cases by using 20lmTl and 99mTc in a subtraction technique. The technique was not useful in identifying hyperplastic parathyroid glands. The technique is recommended as a useful procedure before surgery for primary hyperparathyroidism.
متن کاملTumor imaging using technetium-99m bound to pH-sensitive peptides.
Solid tumors often display metabolic abnormalities that consistently produce low pH in the extracellular space of poorly perfused tissue. These acidic regions may provide a mechanism for drug targeting. Peptides have been designed in such a manner that they exist in an anionic hydrophilic form at the pH of normal tissues, but then undergo a sharp transition to a non-ionic lipophilic form at red...
متن کاملImaging of Primitive Neuroectodermal Tumor (PNET) by Technetium-99m Tetrofosmin
Purpose. Tc-99m tetrofosmin launched for myocardial studies has recently also shown a good detectability for several tumors. Data on PNET imaging by Tc-99m tetrofosmin are not yet available.Patient and method. In the case of a 21-year-old man suffering from pelvis PNET, Tc-99m tetrofosmin scintigraphy was performed additionally to CT and MRI.Results. The gluteal and iliac tumor masses were visu...
متن کاملTechnetium-99m Ceftizoxime Kit Preparation
The aim of this work was to prepare a kit of Tc-ceftizoxime (Tc-CFT), with stability and biological activity preserved, able to identify a septic focus (E. coli) in the experimental infection model in rats. The preparation of the CFT kit involved the use of lyophilized solutions containing the antibiotic ceftizoxime and the sodium dithionite reducing agent (6.0 mg/mL). After lyophilization, the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Inorganica Chimica Acta
سال: 1983
ISSN: 0020-1693
DOI: 10.1016/s0020-1693(00)95333-7